Facilities

Tiofarma operates three manufacturing facilities in Oud-Beijerland, the Netherlands, and holds both EU-GMP and FDA licenses.

At Tiofarma, we pride ourselves on our state-of-the-art facilities that support our comprehensive manufacturing and development capabilities. Our primary manufacturing facility is located in Oud-Beijerland, the Netherlands, and holds both EU-GMP and FDA licenses, ensuring the highest standards of quality and compliance. 

 

Manufacturing facility

Our manufacturing facility in Oud-Beijerland is equipped to handle large-scale production of both nasal sprays and semi-solid formulations, including non-sterile creams, ointments, pastes, and liquids. 

Nasal Spray production 

  • Comprehensive solutions for the development and large-scale manufacturing of uni-dose and bi-dose nasal sprays. 

  • State-of-the-art Grade D qualified manufacturing environment. 

  • Flexible batch sizes to meet varying demand, from small-batch clinical production to full-scale commercial manufacturing. 

  • Advanced quality assurance processes that comply with global regulatory standards, including EMA and FDA guidelines. 

Semi-Solid production

  • Extensive capabilities for the commercial production of semi-solid formulations.
     

  • Advanced technology and state-of-the-art equipment for high-volume production.
     

  • Primary and secondary packaging solutions tailored to meet regulatory and commercial needs.
     

  • Serialization services to ensure global compliance and traceability.
     

  • Flexible production batch sizes to meet demand, from pilot batches to large-scale commercial production.

    More about Semi-Solid production

R&D Facility

Complementing our manufacturing site is a modern, dedicated R&D facility featuring 400 m² of non-GMP clean rooms for formulation and process development. This facility is equipped with innovative R&D solutions and equipment.

Innovative R&D solutions: 

  • Expertise in pre-formulation and formulation development, process development and optimization, and clinical trial material production. 

  • Advanced analytical capabilities, including stability testing, process validation, and comprehensive analytical method development. 

  • Technology transfers and scale-up expertise to ensure efficient and accurate replication of production processes. 

 

Laboratory and Pilot-Scale equipment: 

  • Equipment ranging from a few hundred milliliters to 60 liters, supporting a wide range of development activities. 

  • Advanced analytical laboratory outfitted with cutting-edge physicochemical equipment. 
     

More about our R&D solutions

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